Opioid-sparing effects of diclofenac and paracetamol lead to improved outcomes after cardiac surgery.

Objective: This study assessed the analgesic efficacy, side effects, time to extubation, and oxygenation of 3 analgesic regimens after coronary artery bypass surgery using diclofenac, paracetamol, and placebo suppositories.

Design: Prospective, randomized, double-blind, placebo-controlled study.

Setting: Referral center for cardiothoracic surgery at a university hospital.