Voltage-gated sodium channels in the mammalian heart.

Mammalian species express nine functional voltage-gated Na(+) channels. Three of them, the cardiac-specific isoform Nav1.5 and the neuronal isoforms Nav1.

Structure and function of splice variants of the cardiac voltage-gated sodium channel Na(v)1.5.

Voltage-gated sodium channels mediate the rapid upstroke of the action potential in excitable tissues. The tetrodotoxin (TTX) resistant isoform Na(v)1.5, encoded by the SCN5A gene, is the predominant isoform in the heart.

Voltage-gated Na+ channel transcript patterns in the mammalian heart are species-dependent.

In the present study we investigated whether transcription, alternative splicing and developmental regulation of voltage-gated Na(+) channels occur in a species-dependent manner in the mammalian heart. The composition of the Na(+) channel transcript pool including Na(v)1.1-Na(v)1.

Modulation of Nav1.5 channel function by an alternatively spliced sequence in the DII/DIII linker region.

In the present study, we identified a novel splice variant of the human cardiac Na(+) channel Na(v)1.5 (Na(v)1.5d), in which a 40-amino acid sequence of the DII/DIII intracellular linker is missing due to a partial deletion of exon 17.