Cyclotron production of (99m)Tc: experimental measurement of the (100)Mo(p,x)(99)Mo, (99m)Tc and (99g)Tc excitation functions from 8 to 18 MeV.

Introduction: The cyclotron-based (100)Mo(p,2n)(99m)Tc transformation has been proposed as a viable alternative to the reactor based (235)U(n,f)(99)Mo→(99m)Tc strategy for production of (99m)Tc. Despite efforts to theoretically model the amount of ground-state (99g)Tc present at end of bombardment for the (p,2n) reaction, experimental validation has yet to be performed. The co-production of (99g)Tc may have important implications in both the subsequent radiopharmaceutical chemistry and patient dosimetry upon injection.

A new and simple calibration-independent method for measuring the beam energy of a cyclotron.

This work recommends a new and simple-to-perform method for measuring the beam energy of an accelerator. The proposed method requires the irradiation of two monitor foils interspaced by an energy degrader. The primary advantage of the proposed method, which makes this method unique from previous energy evaluation strategies that employ the use of monitor foils, is that this method is independent of the detector efficiency calibration.

Target specificity of 188Re-labeled B27.1 monoclonal antibodies to ovarian cancer cells in vivo.

Background: Currently we are exploring a new multistep pretargeting approach involving administration of a bispecific antibody (B27.1 x P54) which has an anti-CA-125 (B27.1) and antibiotin (P54) paratope.

A quantitative and comparative study of radionuclidic and chemical impurities in water samples irradiated in a niobium target with Havar vs. niobium-sputtered Havar as entrance foils.

Enriched and natural abundance water samples were irradiated in a niobium (Nb) chamber target with Havar and Nb-sputtered Havar foils. Irradiations were performed with 17.5MeV protons at currents from 35 to 100microA lasting for 1-2.

Use of a simulated annealing algorithm to fit compartmental models with an application to fractal pharmacokinetics.

Increasingly, fractals are being incorporated into pharmacokinetic models to describe transport and chemical kinetic processes occurring in confined and heterogeneous spaces. However, fractal compartmental models lead to differential equations with power-law time-dependent kinetic rate coefficients that currently are not accommodated by common commercial software programs. This paper describes a parameter optimization method for fitting individual pharmacokinetic curves based on a simulated annealing (SA) algorithm, which always converged towards the global minimum and was independent of the initial parameter values and parameter bounds.