Publications by authors named "Stergios Papachatzopoulos"
Lipid Profile after Pharmacologic Discontinuation and Restoration of Menstruation in Women with Endometriosis: A 12-Month Observational Prospective Study.
J Clin Med
August 2023
The lipid profile is affected following menstrual cessation (MC). We aimed to evaluate the effects of goserelin-induced MC and subsequent menstrual restoration (MR) on lipid metabolism. Premenopausal women with histologically verified endometriosis (n = 15) received goserelin monthly for 6 months (6mο), resulting in MC, and were followed-up for another 6 months after MR (12mο).
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- Goserelin, a GnRH analog, induced menstrual cessation in premenopausal women, leading to significant reductions in bone mineral density (BMD) at both lumbar spine and femoral neck after 6 months.
- After 6 months of menstrual restoration, lumbar spine BMD showed some recovery but remained lower than baseline levels, while femoral neck BMD stayed stable. Bone turnover markers initially increased but decreased again by the 12-month mark.
- Changes were noted in specific circulating microRNAs related to bone metabolism, with significant downregulation at 6 months and a robust increase in expression at 12 months, suggesting altered bone remodeling processes.
Background: Struma ovarii is a rare cause of hyperthyroidism, while coexistence with Graves' disease has been scarcely reported.
Patient Findings: We report a patient with Graves' disease and unilateral benign functioning struma ovarii, accompanied by ascites, pleural effusion and elevated cancer antigen-125 (CA-125) levels. In subsequent thyroidectomy, incidental papillary thyroid carcinoma was also identified.