Malignant gliomas are common central nervous system tumors that pose a significant clinical challenge due to the lack of effective treatments. Glioblastoma (GBM), a grade 4 malignant glioma, is the most prevalent primary malignant brain tumor and is associated with poor prognosis. Current clinical trials are exploring various strategies to combat GBM, with oncolytic viruses (OVs) appearing particularly promising.
View Article and Find Full Text PDFDevelopment of successful cancer therapeutics requires exploration of the differences in genetics, metabolism, and interactions with the immune system among malignant and normal cells. The clinical observation of spontaneous tumor regression following natural infection with microorganism has created the premise of their use as cancer therapeutics. Oncolytic viruses (OVs) originate from viruses with attenuated virulence in humans, well-characterized vaccine strains of known human pathogens, or engineered replication-deficient viral vectors.
View Article and Find Full Text PDFThe world has been afflicted by the rise of misinformation. The sheer volume of news produced daily necessitates the development of automated methods for separating fact from fiction. To tackle this issue, the computer science community has produced a plethora of approaches, documented in a number of surveys.
View Article and Find Full Text PDFThe Internet of Medical Things (IoMT) couples IoT technologies with healthcare services in order to support real-time, remote patient monitoring and treatment. However, the interconnectivity of critical medical devices with other systems in various network layers creates new opportunities for remote adversaries. Since most of the communication protocols have not been specifically designed for the needs of connected medical devices, there is a need to classify the available IoT communication technologies in terms of security.
View Article and Find Full Text PDFPurpose: To compare Icare ONE rebound self-tonometer (ICRBT) measurements with Goldman applanation tonometry (GAT).
Methods: A trained examiner instructed each of 60 normal subjects on use of the ICRBT. Each subject then took two measurements of his/her own pressure using the ICRBT.
The case of a patient who had an unsuspected perforated adenocarcinoma of the appendix discovered during operation for a sigmoid carcinoma is presented. The problems in diagnosing carcinoma of the appendix are discussed and the literature is reviewed.
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