[To the Problem of Selection of Antihypertensive Therapy Scheme From Position of Cost of Treatment].

The article is devoted to pharmacoeconomic aspects of treatment of arterial hypertension including its combination with diabetes mellitus. Data of four studies of comparison of clinical and economical effectiveness of treatment with original enalapril and its fixed combination with hydrochlorothiazide with some generic preparations of enalapril are presented. It has been shown that original enalapril has advantages over generics and from position of treatment cost.

Magnesium orotate in severe congestive heart failure (MACH).

Background: Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication.

Methods: In a monocentric, controlled, double-blind study, 79 patients with severe congestive heart failure (NYHA IV) under optimal medical cardiovascular treatment were randomised to receive either magnesium orotate (6000 mg for 1 month, 3000 mg for about 11 months, n = 40) or placebo (n = 39). Both groups were comparable in demographic data, duration of heart failure and pre- and concomitant treatment.

Magnesium orotate in severe congestive heart failure (MACH).

Background: Aim of this study was to evaluate adjuvant magnesium orotate on mortality and clinical symptoms in patients with severe heart failure under optimal cardiovascular medication.

Methods: In a monocentric, controlled, double-blind study, 79 patients with severe congestive heart failure (NYHA IV) under optimal medical cardiovascular treatment were randomised to receive either magnesium orotate (6000 mg for 1 month, 3000 mg for about 11 months, n=40) or placebo (n=39). Both groups were comparable in demographic data, duration of heart failure and pre- and concomitant treatment.

[Low ability of blood lymphocytes to produce interferon-gamma in patients with idiopathic prolapse of mitral valve].

Aim: To examine lymphocyte ability to synthetize interferon-gamma in patients with mitral prolapse (MP).

Material And Methods: The diagnosis of MP was made in 75 patients at echocardiography. ECG monitoring was made and the study of the ability of blood lymphocytes to produce IFN-gamma (If-g).

[Orotic acid as a metabolic agent].

The paper reviews clinical and experimental studies into the mechanisms of action of orotic acid (OA). OA has been shown to take an active participation in metabolic processes in the body. As a pyrimidine precursor, it plays a key role in the biosynthesis of nucleic acids and protein, regulates water-salt exchange, by increasing diuresis and reducing the volume of extracellular fluid.

[New approaches to the treatment of patients with idiopathic mitral valve prolapse].

Aim: To assess efficiency of magnerot, magnesium orotate, in patients with idiopathic mitral prolapse (IMP).

Material And Methods: 84 patients with IMP were randomized to the study group (43 patients) and control group (41 patients). Patients of the study group received magnerot tablets (Germany) containing 500 mg of magnesium orotate (daily dose 3000 mg) for 6 months.

[Results of 24-hours arterial blood pressure monitoring in patients with mitral prolapse and anomalous chorda].

Aim: To examine 24-h arterial hypertension (AH) profile in patients with connective tissue dyplasia syndrome (CTDS).

Materials And Methods: 92 patients (35 males and 57 females) with CTDS aged 18-37 years. 68 had mitral prolapse stage I-II, of them 23 had anomalous chorda.

[Studies on the function of external respiration in adults and children with anomalous position of the heart chordae].

Aim: To compare respiratory function in adults and children whose heart chordae were in anomalous position (AC) with reference to severity of heart connective tissue dysplasia syndrome.

Materials And Methods: The study included ninety one 6-14-year-olds and 125 adults with AC. The patients were divided into groups by the degree of atrioventricular valvular prolapse (AVVP).

[Autonomic regulation of cardiac activity and the status of central hemodynamics in patients with idiopathic mitral valve prolapse].

The vegetative regulation of heart rhythm was estimated from mathematical analysis of heart rhythm in 79 patients with prolapse of mitral valve (PMV) and in 15 patients with abnormal position of chordae (ADC). The sympathetic tone elevation was more typical for patients with HMV. Meanwhile the decrease of sympathetic tone was observed in patients with PMV and ADC with vegetative crises in anamnesis.

[The characteristics of the clinical picture in patients with idiopathic mitral valve prolapse and with anomalous chordae tendineae].

95 patients with idiopathic mitral prolapse (IMP) and 20 patients with anomalous chorda (AC) were evaluated clinically. 13 symptoms and syndromes significantly different from control were distinguished in IMP patients. 12 of them indicated the presence of vegetative dystonia.

[Markers of connective tissue dysplasia in patients with idiopathic atrioventricular valve prolapse and anomalously sited chordae tendineae].

Phenotype was investigated in 86 patients with idiopathic prolapses of atrioventricular valves and in 21 patients with displaced chordae. 10 and 4 markers of connective tissue dysplasia were distinguished for patients with the prolapses and anomalous chordae, respectively. For patients with dysplasia of connective tissue of the heart a modified version of phenotypical length is proposed: norm-anomalous chordae--prolapse of the 1st degree--prolapse of the 2nd degree.

[Glucocorticoid functional characteristics of the adrenals in the terminal complications of acute myocardial infarct].

A follow-up study in the blood of the total, free and bound 11-oxycorticosteroids (11-OCS) and reserve binding capability of transcortin (RBCT) in 246 patients with acute myocardial infarction, complicated in 127 with cardiogenic shock, in 62 by ventricular fibrillation and in 57 by cardiac rupture was undertaken. In patients with acute myocardial infarction there was statistically reliable increased activation of glucocorticoid function of the adrenals with simultaneous marked drop of RBCT as compared with patients who had uncomplicated myocardial infarction. The greatest changes were found in patients with true cardiogenic shock and shock with cardiac rupture.

[Anti-arrhythmic and hemodynamic effects of visken and glucagon in rhythm disorders in the acute phase of myocardial infarct].

Combination of the beta-adrenergic blocking agent visken with glucagon in the acute period of myocardial infarction possesses higher antiarrhythmic activity with a negligible cardiodepressive effect as compared to that of isolated administration of visken and leads to a decrease in the excessive production of catecholamines and glucocorticoids in the blood.

[Change in adrenal glucocorticoid function in myocardial infarct complicated by cardiogenic shock].

The article deals with the results of study of bound and free 11-oxycorticosteroids and the reserve binding capacity of transcortin in 65 patients with myocardial infarction complicated by various types of cardiogenic shock. The most significant increase in the level of 11-oxycorticosteroids and decrease in transcortin reserve binding capacity were found in patients with true cardiogenic shock.

[Adrenal cortex hormones in acute myocardial infarct complicated by pulmonary edema].

The results of the study of adrenal cortical function in 94 patients (including 20 patients with acute myocardial infarction and pulmonary edema) and in 20 practically healthy persons are discussed. Marked activation of adrenal cortical hormones was noted in patients with acute myocardial infarction and edema of the lungs.