Publications by authors named "Stephen W R Harrison"

The family comprising positive-sense RNA viruses, is characterised by its non-enveloped, small virions, broad host range, and notable tendency for host switching. These viruses are primarily associated with gastroenteric disease, though they can lead to haemorrhagic or respiratory infections. Our study employed a metagenomics analysis of faecal samples from stoats (), identifying two novel calicivirus species, named stoat vesivirus and stoat valovirus.

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Repeat spillover of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) into new hosts has highlighted the critical role of cross-species transmission of coronaviruses and establishment of new reservoirs of virus in pandemic and epizootic spread of coronaviruses. Species particularly susceptible to SARS-CoV-2 spillover include Mustelidae (mink, ferrets and related animals), cricetid rodents (hamsters and related animals), felids (domestic cats and related animals) and white-tailed deer. These predispositions led us to screen British wildlife with sarbecovirus-specific quantitative PCR and pan coronavirus PCR assays for SARS-CoV-2 using samples collected during the human pandemic to establish if widespread spillover was occurring.

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Horseshoe bats are the natural hosts of the subgenus that includes SARS-CoV and SARS-CoV- 2. Despite the devastating impact of the COVID-19 pandemic, there is still little known about the underlying epidemiology and virology of sarbecoviruses in their natural hosts, leaving large gaps in our pandemic preparedness. Here we describe the results of PCR testing for sarbecoviruses in the two horseshoe bat species ( and ) present in Great Britain, collected in 2021-22 during the peak of COVID-19 pandemic.

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Article Synopsis
  • Carnivores like the red fox show weak genetic structure across large areas, complicating the tracking of their post-glacial movement patterns.
  • This study utilized genome-wide data from 524 red foxes to explore variations and genetic mixing across European populations, revealing important refugial areas and endemism, particularly in Spain.
  • The research also tested various recolonization scenarios post-Last Glacial Maximum, concluding that natural colonization of Ireland was more plausible than human introduction, suggesting a richer mammalian community on the island during the early post-glacial era.
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Endangered species recovery plans often include captive breeding and reintroduction, but success remains rare. Critical for effective recovery is an assessment of captivity-induced changes in adaptive traits of reintroduction candidates. The gut microbiota is one such trait and is particularly important for scavengers exposed to carcass microbiomes.

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Utilisation of animal personality has potential benefit for conservation management. Due to logistics of robust behavioural evaluation in situ, the majority of studies on wild animals involve taking animals into captivity for testing, potentially compromising results. Three in situ tests for evaluation of boldness in San Joaquin kit fox () were developed (ENOT: extended novel object test; RNOT: rapid novel object test; TH: trap/handling test).

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