Randomized controlled clinical study evaluating the efficacy and safety of intratumoral treatment of canine mast cell tumors with tigilanol tiglate (EBC-46).

Objective: To evaluate the efficacy and safety of tigilanol tiglate (TT) for local intratumoral treatment of mast cell tumors (MCTs) in dogs.

Methods: A randomized controlled clinical study in 2 phases involving 123 dogs with cytologically diagnosed MCT. Phase 1 compared 81 TT-treated dogs with 42 control dogs; phase 2 allowed TT treatment of control dogs and retreatment of dogs that failed to achieve tumor resolution after TT treatment in phase 1.

Toward a veterinary informatics research agenda: an analysis of the PubMed-indexed literature.

Purpose: Veterinary medicine and human health are inextricably intertwined. Effective tracking of veterinary information - veterinary informatics - impacts not only veterinary medicine, but also public health, informatics research, and clinical care. However, veterinary informatics has received little attention from the general biomedical informatics community.