Significance of Basal Cell Carcinomas Exhibiting Intravascular Invasion.

Intravascular invasion of tumor cells can be associated with metastasis in many cancers. Basal cell carcinomas (BCCs), however, rarely metastasize; therefore, the clinical impact of intravascularly invasive BCC (IVBCC) is currently unclear. Because of these facts and the rarity of IVBCC, questions have arisen on whether IVBCC truly exists.

Keeping the power on to home medical devices.

Advances in digital health technologies have revolutionised home medical care. Yet many home medical devices (HMEDs, which includes devices referred to as 'life support equipment') rely upon a stable and resilient electricity supply. For users of HMEDs, interruptions to electricity supply can compromise treatment, well-being or survival.

Eccrine Porocarcinoma Treated by Mohs Micrographic Surgery: Over 6-Year Follow-up of 12 Cases and Literature Review.

Background: Eccrine porocarcinoma (EPC) has a poor prognosis after standard wide local excision (WLE), with 20% local recurrence, 20% regional and 12% distant metastatic rates. Mohs micrographic surgery (MMS) has been used as a promising treatment.

Objective: To review the use of MMS for EPC and assess treatment outcomes.

A phase III skin cancer chemoprevention study of DFMO: long-term follow-up of skin cancer events and toxicity.

Decreasing the incidence of nonmelanoma skin cancer (NMSC) is of great importance in regards to future healthcare services. Given the previously reported preventive effects of α-difluoromethylornithine (DFMO) in skin and colon cancer trials, we determined appropriate cause to update the clinical data on the subjects from the recently reported randomized, double-blind, placebo-controlled phase III skin cancer prevention study of DFMO. Our intention was to retrospectively assess the further incidence of skin cancer, other malignancies, and adverse events of patients accrued to our phase III skin cancer prevention study of DFMO.

Transportation behaviours of older adults: an investigation into car dependency in urban Australia.

Aim: Increased car dependency among Australia's ageing population may result in increased social isolation and other health impacts associated with the cessation of driving. While public transport represents an alternative to car usage, patronage remains low among older cohorts. This study investigates the facilitators and barriers to public transport patronage and the nature of car dependence among older Australians.

Desmoplastic trichoepithelioma, infiltrative/morpheaform BCC, and microcystic adnexal carcinoma: differentiation by immunohistochemistry and determining the need for Mohs micrographic surgery.

Several important cutaneous neoplasms present with basaloid cells in the dermis. Desmoplastic trichoepithelioma (DTE), infiltrative/morpheaform basal cell carcinoma (BCC), and microcystic adnexal carcinoma (MAC) are tumors in this category that may be difficult to differentiate, especially when evaluating thin biopsy specimens. An accurate diagnosis has important clinical implications.

Psychic centrality: reflections on two psychohistoriographic cultural therapy workshops in Montreal.

The use of psychohistoriographic cultural therapy (PCT) developed in Jamaica is described in the context of two workshops in Montreal. PCT is a form of group intervention that seeks to elicit and clarify the "psychic centrality" of a group. Psychic centrality refers to a sense of psychological containment or organization of diverse individual points of view through creating a historical map of collective experience.

Sebaceous cell carcinoma of the eyelid: a rapidly enlarging lesion with massive xanthogranulomatous inflammation.

A 76-year-old man presented atypically with a 4-week history of a rapidly enlarging ulcerated nodular lesion of the left upper eyelid that was found to be sebaceous cell carcinoma. Further investigation showed no metastatic disease, and Mohs surgery was performed to resect the tumor. Histopathologic analysis showed features diagnostic of sebaceous cell carcinoma.

Cutaneous adenoid cystic carcinoma with perineural invasion treated by mohs micrographic surgery-a case report with literature review.

We report a 58-year-old woman with cutaneous adenoid cystic carcinoma arising on the chest treated with Mohs micrographic surgery. The patient remained tumor-free at 24-month follow-up. To date, only six other cases of cutaneous adenoid cystic carcinoma were reportedly managed by Mohs surgery.

Proteomic identification of binding partners for the brain metabolite lanthionine ketimine (LK) and documentation of LK effects on microglia and motoneuron cell cultures.

Lanthionine ketimine (LK) represents a poorly understood class of thioethers present in mammalian CNS. Previous work has indicated high-affinity interaction of LK with synaptosomal membrane protein(s), but neither LK binding partners nor specific bioactivities have been reported. In this study, LK was chemically synthesized and used as an affinity agent to capture binding partners from mammalian brain lysate.

A randomized, double-blind, placebo-controlled phase 3 skin cancer prevention study of {alpha}-difluoromethylornithine in subjects with previous history of skin cancer.

Preclinical studies have shown that the inhibition of ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) and resultant decreases in tissue concentrations of polyamines (putrescine and spermidine) prevents neoplastic developments in many tissue types. Clinical studies of oral DFMO at 500 mg/m(2)/day revealed it to be safe and tolerable and resulted in significant inhibition of phorbol ester-induced skin ODC activity. Two hundred and ninety-one participants (mean age, 61 years; 60% male) with a history of prior nonmelanoma skin cancer (NMSC; mean, 4.

Assessing and achieving accuracy in digital dental photography.

Accurate digital photography is becoming part of the standard of care for diagnosis and documentation in dental treatment. Proper exposure and color rendering are critical elements in the capture of useful images with excellent representational quality. Reliable photographic techniques must be consistently applied as a repeatable protocol to create an accurate record of pretreatment conditions and post-treatment results.

Contemporary dental photography: selection and application.

Technological developments in photography have continued to facilitate and enhance the practice of dentistry. This evolution to a contemporary photographic process is revolutionizing the way clinicians diagnose, treat, and communicate with patients and colleagues. In this technologically progressing profession, clinicians should consider using an objective strategy for the selection and application of a reliable camera system that best suits the needs of their practice.

Strategies for successful esthetic dental treatment.

The foundational principles of esthetic smiles reveal the direct influence of individual tooth alignment on dentofacial relationships. The use of clinical photography is an essential means to identify esthetic problems. Smile design provides an opportunity for effective communication to discuss treatment alternatives with the patient in the consultation process.

Observations on the fibrous retinacula of the heel pad.

Background: The original purpose of the study was to clarify whether or not there is continuity of the Achilles tendon and the plantar fascia. Those findings have been previously published. In the course of that study, observations of the anatomy of the retinacular tethers of the heel pad were made.

Dental photography systems: required features for equipment selection.

Photographic images are becoming a standard of care for visual communication and medicolegal documentation in contemporary dentistry. For visual images to be effective in diagnosis and treatment planning they must capture useful visual information. Repeatable and predictable image alignment, magnification, and exposure are required for predictable macrophotography in dental practice.

Pilomatrix carcinoma of the back treated by mohs micrographic surgery.

Background: Pilomatrix carcinoma (synonyms, matrical carcinoma or malignant pilomatrixoma) is a rare malignant neoplasm derived from the hair matrix first described in 1980. This neoplasm can exhibit local aggressive behavior and distant metastasis. Most pilomatrix carcinomas occur on the head and neck of elderly individuals with a predilection for males (M:F 5:1).

Dermatofibrosarcoma protuberans: a report on 29 patients treated by Mohs micrographic surgery with long-term follow-up and review of the literature.

Background: Dermatofibrosarcoma protuberans (DFSP) is an uncommon tumor of the skin. Clinically, it often masquerades as a benign, indolent tumor on the trunk and extremities. Microscopically, it extends far beyond assessed clinical margins, spreading locally in the dermis, subcutaneous tissue, and muscle.

Repeatable alignment--Part II: Consistent photographic alignment accuracy.

Predictable aesthetic results necessitate the implementation of various dental principles for tooth display, alignment, and relative proportion. In order to ensure accurate communication, clinicians must clearly document visual information regarding violations of these tooth arrangement principles via dental photography. Accuracy in the alignment of photographs is crucial for subsequent treatment planning and evaluation.

Repeatable alignment--Part 1: Consistent model transfer record accuracy.

Successful restorative treatment requires the application of aesthetic dental principles that include guidelines for proper tooth alignment. Clinicians use mounted models in diagnosis and treatment when these aesthetic principles are violated. Accurately mounted casts are indispensable for precise communication with patients, specialists, and laboratory technicians, and will influence proper diagnosis and subsequent treatment.