A Phase I, Single Ascending Dose Study of GEM103 (Recombinant Human Complement Factor H) in Patients with Geographic Atrophy.

Purpose: To establish the safety, tolerability, pharmacokinetics, and pharmacodynamics of an intravitreal injection of recombinant human complement factor H (CFH), GEM103, in individuals with genetically defined age-related macular degeneration (AMD) and geographic atrophy (GA).

Design: Phase I single ascending-dose, open-label clinical trial (ClinicalTrials.gov identifier, NCT04246866).

Intravitreal ranibizumab for macular edema secondary to central retinal vein occlusion.

Purpose: To evaluate the safety and efficacy of intravitreal ranibizumab for macular edema secondary to central retinal vein occlusion.

Methods: Patients with macular edema secondary to perfused central retinal vein occlusion were enrolled in this ongoing, prospective, open-label study. Treatment was initiated with monthly intravitreal ranibizumab for 3 months.

Diffuse neonatal hemangiomatosis presenting as bilateral iris hemangiomas in an infant.

Purpose: To describe a case of diffuse neonatal hemangiomatosis presenting as bilateral iris hemangiomas.

Method: Case report.

Patient: A 2-month-old girl presented with bilateral enlarging red masses of her irises, congestive heart failure, and abdominal distension.

Spectral domain optical coherence tomography for proliferative diabetic retinopathy with subhyaloid hemorrhage.

A prototype 6-microm axial resolution spectral domain optical coherence tomography (SD-OCT) device was used to image the retina of a patient with uncontrolled diabetes mellitus who had proliferative diabetic retinopathy with subhyaloid hemorrhage. A raster scan pattern with 128 B-scans covering a 6 X 6 X 2-mm volume of the retina was obtained. SD-OCT showed the presence of blood localized between the internal limiting membrane and the posterior hyaloid face and allowed visualization of the cross sectional retinal architecture and the vitreoretinal interface at different horizontal levels that could be registered with the color fundus photograph.

Laser treatment of Coats' disease.

A 9-year-old boy presented with an exudative retinal detachment, vascular telangiectasias, subretinal lipid, and retinal macrocyst formation. He underwent three sessions of large-spot diode laser for the treatment of Coats' disease. Serial examinations and fundus photography documented an excellent involutional response with an improvement in visual acuity.

Outcomes of surgery for idiopathic macular hole: a case-control study comparing silicone oil with gas tamponade.

Background And Objective: To compare outcomes of macular hole surgery using silicone oil with C3F8 gas tamponade.

Patients And Methods: A retrospective case-control study of patients who underwent macular hole surgery for stage 2, 3, or 4 macular holes.

Results: Forty-six eyes of 44 patients underwent macular hole surgery involving injection of silicone oil (23 cases) or gas tamponade (23 controls).