Potential for thermal damage to the blood-brain barrier during craniotomy: implications for intracortical recording microelectrodes.

Objective: Our objective was to determine how readily disruption of the blood-brain barrier (BBB) occurred as a result of bone drilling during a craniotomy to implant microelectrodes in rat cortex. While the phenomenon of heat production during bone drilling is well known, practices to evade damage to the underlying brain tissue are inconsistently practiced and reported in the literature.

Approach: We conducted a review of the intracortical microelectrode literature to summarize typical approaches to mitigate drill heating during rodent craniotomies.

The numerical mirage method for photothermal characterization of materials.

Noncontact thermal measurement techniques offer rapid thermal characterization without modification or destruction of the sample being studied. A simple and versatile method has been developed, termed the "numerical mirage method," that utilizes the transient photothermal deflection of a laser beam traversing a modulated temperature gradient. This method expands the range and simplifies the experimental procedure of traditional mirage methods.

Pressure wave propagation in a shaken granular bed.

Pressure waves in a granular material travel through particle contact points and are primarily transmitted by the "force chains" that carry most of the load in a granular medium. However, these force chains tend to be fragile and ephemeral and can be disrupted by very minor perturbations including the waves themselves. External vibration also disrupts the force chains and therefore also changes the wave propagation characteristics.

Pressure wave propagation in a granular bed.

The transmission of pressure waves in granular materials is complicated by the heterogeneity and nonlinearity inherent in these systems. Such waves are propagated through particle contacts primarily along the "force chains" which carry most of the load in granular materials. These fragile and ephemeral chains coupled with irregular particle packing lead to the observed heterogeneity.