Phytotoxic and Antifungal Activity of (-)-Penienone Produced by Penicillium palitans (Ascomycota) Isolated from Deep Sea Sediments in the Southern Ocean, Maritime Antarctica.

Metabolites isolated from Penicillium palitans, obtained from deep sea sediments in the maritime Antarctica, were investigated for phytotoxic and antifungal activities. The fungus was submitted to solid state fermentation, and its crude extract was produced. Chromatographic separations of the P.

A survey of synthetic and natural phytotoxic compounds and phytoalexins as potential antimalarial compounds.

The apicomplexan parasites pathogens such as Plasmodium spp. possess an apicoplast, a plastid organelle similar to those of plants. The apicoplast has some essential plant-like metabolic pathways and processes, making these parasites susceptible to inhibitors of these functions.

Antileishmanial activity of natural diterpenes from Cistus sp. and semisynthetic derivatives thereof.

Eleven cis-clerodane diterpenes, seven labdane type diterpenes and one triterpene isolated from Cistus monspeliensis and the resin "Ladano" of Cistus creticus subsp. creticus were evaluated against Leishmania donovani promastigotes, the causative agent for visceral leishmaniasis. In addition, eleven semisynthetic manoyl oxide, seventeen labdane type derivatives and a triterpene were also evaluated for their antileishmanial activity.