A Review of Potentially Toxic Elements in Sediment, Water, and Aquatic Species from the River Ecosystems.

There is concern over potential toxic elements (PTEs) impacting river ecosystems due to human and industrial activities. The river's water, sediment, and aquatic life are all severely affected by the release of chemical and urban waste. PTE concentrations in sediment, water, and aquatic species from river ecosystems are reported in this review.

Distribution of potentially toxic elements in sediments of the municipal river channel (Balu), Dhaka, Bangladesh: Ecological and health risks assessment.

The concern of potential toxic elements (PTEs) contamination in the river ecosystem is growing due to anthropological activity. The contents of seven PTEs in sediments from the Balu River channel were analyzed using atomic absorption spectroscopy (AAS) and an environmental risk model. Several PTEs were found in the sediment at high levels, including zinc (Zn), copper (Cu), arsenic (As), lead (Pb), cadmium (Cd), nickel (Ni), and mercury (Hg), that might pose a risk to human and ecological health.

Potentially toxic elements (PTEs) in the invasive Asian clam (Corbicula fluminea) from polluted urban river areas of Bangladesh and evaluation of human health risk.

The invasive Asian clam species, Corbicula fluminea, has significant ecological and societal implications at both local and international levels due to its nutritional aspects. C. fluminea from four urban rivers in Bangladesh exhibited negative allometric growth and degree of contamination with potentially toxic elements (PTEs), which posed a concern to human health based on the AAS and USEPA risk models.

Immediate health risk: Concentration of heavy metals in contaminated freshwater fishes from the river channel of Turag-Tongi-Balu.

The consumption of contaminated finfish from the polluted river channel of Turag-Tongi-Balu, Kamarpara site, Dhaka poses significant health hazards to humans. We used mass spectrometry on chemically digested liquid samples from five fish species from Turag-Tongi-Balu to estimate the concentrations of 10 elements (Cr, Mn, Ni, Cu, Zn, As, Se, Cd, Fe, and Pb). Except M.

The role of human resource management and governance in addressing bullying, burnout and the depersonalization of junior and senior psychiatric nurses in Saudi Arabia.

This study examined the level of perceived responsibility junior and senior psychiatric nurses have for human resources and governance in Saudi Arabia. Bullying is a significant issue in nursing and an entrenched cultural practice that highlights a failure in governance and human resource responsibilities. A total of 90 responses (43.

Linearity Characterization and Uncertainty Quantification of Spectroradiometers via Maximum Likelihood and the Non-parametric Bootstrap.

A technique for characterizing and correcting the linearity of radiometric instruments is known by the names the "flux-addition method" and the "combinatorial technique". In this paper, we develop a rigorous uncertainty quantification method for use with this technique and illustrate its use with both synthetic data and experimental data from a "beam conjoiner" instrument. We present a probabilistic model that relates the instrument readout to a set of unknown fluxes via a set of polynomial coefficients.

Corrigendum: Phylogeny and Taxonomy on Cryptic Species of Forked Ferns of Asia.

[This corrects the article DOI: 10.3389/fpls.2021.

Phylogeny and Taxonomy on Cryptic Species of Forked Ferns of Asia.

Cryptic species comprise two or more taxa that are grounded under a single name because they are more-or-less indistinguishable morphologically. These species are potentially important for detailed assessments of biodiversity, but there now appear to be many more cryptic species than previously estimated. One taxonomic group likely to contain many cryptic species is , a genus of forked ferns that occurs commonly along roadsides in Asia.

Resolving phylogenetic and classical nomenclature: A revision of Seraphsidae Jung, 1974 (Gastropoda: Neostromboidae).

This revision demonstrates that an integrated taxonomic approach to classical taxonomic practice can lead to increased internal cladistic resolution within a clade, including the recognition of new taxa at all nomenclatural levels. In particular, this revision has two aims: 1) to complete an α-taxonomic revision of Seraphsidae (Stromboidea); and 2) to resolve the infrafamilial relationships within Seraphsidae using morphological cladistics. An annotated synonymy was generated for each taxon, the precedence of names determined, and revised descriptions formulated.

Quantification of azacitidine incorporation into human DNA/RNA by accelerator mass spectrometry as direct measure of target engagement.

We report an accelerator mass spectrometry (AMS) assay to quantify azacitidine (Aza) incorporation into DNA and RNA from human acute myeloid leukemia (AML) cells, mouse bone marrow (BM) and peripheral blood mononuclear cells (PBMCs). Aza, a cytidine nucleoside analogue, is a disease modifying pharmacological agent used for treatment of myelodysplastic syndromes (MDS) and AML. Our assay was able to directly quantify the complex of Aza incorporated into DNA/RNA, via isolation of DNA/RNA from matrix (i.

Corrigendum: Recognising and defining a new crown clade within Stromboidea Rafinesque, 1815 (Mollusca, Gastropoda). ZooKeys 867: 1-7. https://doi.org/10.3897/zookeys.867.34381.

[This corrects the article DOI: 10.3897/zookeys.867.

Recognising and defining a new crown clade within Stromboidea Rafinesque, 1815 (Mollusca, Gastropoda).

This paper defines a new crown clade Neostromboidea to separate the Strombidae, Rostellariidae, and Seraphsidae from their sister families Struthiolariidae and Aporrhaidae. There is significant value to understanding evolutionary processes within Stromboidea to recognise the universal similarity in the position of the eye on the end of peduncles and a diminished cephalic tentacle that arises from the middle to the end on that peduncle. This is in contrast to other members of the Stromboidea where the eye is located at the base of the cephalic tentacle.

Boerhaave's syndrome in an ultra-distance runner.

A runner competing in a 100 mile trail race presented with severe lower chest pain and right upper abdominal pain. His pain started immediately after he took an over the counter non steroidal anti-inflammatory pill a few hundred metres after leaving the aid station. When he took the pill, he immediately had to vomit and spit out the pill.

Association of an Emergency Department-Based Intensive Care Unit With Survival and Inpatient Intensive Care Unit Admissions.

Importance: Increased patient acuity, decreased intensive care unit (ICU) bed availability, and a shortage of intensivist physicians have led to strained ICU capacity. The resulting increase in emergency department (ED) boarding time for patients requiring ICU-level care has been associated with worse outcomes.

Objective: To determine the association of a novel ED-based ICU, the Emergency Critical Care Center (EC3), with 30-day mortality and inpatient ICU admission.

Population Pharmacokinetics of an Anti-PD-L1 Antibody, Durvalumab in Patients with Hematologic Malignancies.

Background And Objectives: Durvalumab, a human monoclonal antibody targeting programmed cell death ligand 1, has been approved for urothelial carcinoma and stage III non-small cell lung cancer by the US Food and Drug Administration and is being evaluated in various malignancies. The objective of this study was to develop a population-pharmacokinetic model of durvalumab in patients with various hematologic malignancies and to investigate the effects of demographic and disease factors on the pharmacokinetics in this population.

Methods: A total of 1812 concentrations from 267 patients with myelodysplastic syndromes, acute myeloid leukemia, multiple myeloma, non-Hodgkin lymphoma, or Hodgkin lymphoma were included in the analysis.

Laevistrombus Abbott 1960 (Gastropoda: Strombidae): Indian and southwest Pacific species.

Here we evaluate the taxonomy of the marine gastropod genus Laevistrombus Abbott, 1960 and determine that there are five extant species within this genus, three of which occur in the southwest Pacific. Comparative analyses of this complex have been problematic due to the lack of designated type material. Therefore, we present the type material for L.

Quantification of XRCC and DNA-PK proteins in cancer cell lines and human tumors by LC-MS/MS.

Background: The x-ray repair cross-complementing (XRCC) proteins and a catalytic subunit of nuclear DNA-dependent serine/threonine protein kinase (DNA-PK) play important roles in cancer biology. Understanding the protein expression levels allows us to reconstruct in vivo functionality and to qualify protein biomarkers.

Methods & Results: XRCC and DNA-PK proteins in human cancer cells and tumor tissues have been identified and quantified by selected peptides using NanoLC and high-resolution mass spectrometry.

No differences in the pharmacodynamics and pharmacokinetics of the thrombin receptor antagonist vorapaxar between healthy Japanese and Caucasian subjects.

Background: Vorapaxar, a novel antiplatelet agent in advanced clinical development for the prevention and treatment of atherothrombotic disease, is a potent, orally bioavailable thrombin receptor antagonist selective for the protease-activated receptor 1 (PAR-1).

Methods: Since race/ethnicity may affect the safety, efficacy and dosage of drugs, this study was conducted to evaluate potential differences in the pharmacodynamics, pharmacokinetics and safety of vorapaxar after single (5, 10, 20, or 40 mg) or multiple (0.5, 1, or 2.

Cardiovascular supply cost negotiations: partnering for the future.

As a major expense driver to cardiovascular programs, supply costs related to electrophysiology and cardiac catheterization procedures directly link to the overall financial health of organizations associated with those programs. Because of this, it is important that institutions establish a logical and resolute approach to obtaining supply pricing that maximizes cost-saving opportunities, buffers their organizations from escalating costs related to the advances in available technologies, defines supply chain expectations while preserving clinicians' access to high-quality cardiovascular supplies, and maintains the availability of the full spectrum of products to our physicians, referring physicians, and patients. In a joint effort with physicians, administration, and suppliers, and in the spirit of partnership, the University of Michigan Health System has developed and implemented such a model that illustrates the opportunities to be gained.

Interaction of single-dose ezetimibe and steady-state cyclosporine in renal transplant patients.

This open-label, single-period study evaluated the single-dose pharmacokinetics of ezetimibe (EZE) 10 mg in the setting of steady-state cyclosporine (CyA) dosing in renal transplant patients. A single 10-mg dose of EZE was coadministered with the morning dose of CyA (75-150 mg twice a day). Total EZE (sum of unconjugated, parent EZE and EZE-glucuronide; EZE-total) AUC(0-last) and Cmax were compared to values derived from a prespecified database of healthy volunteers.

The effect of fluvastatin on the pharmacokinetics and pharmacodynamics of ezetimibe.

Objective: The objective of this study was to evaluate the pharmacodynamic effects and safety of the co-administration of ezetimibe and fluvastatin in healthy hypercholesterolemic subjects at clinically-relevant doses and to evaluate the potential for a pharmacokinetic drug interaction between ezetimibe and fluvastatin.

Methods: In a single-center, evaluator-blind, placebo-controlled, multiple-dose, parallel-group study 32 healthy subjects with hypercholesterolemia were randomized to 4 treatments administered once daily for 14 days: ezetimibe 10 mg plus ezetimibe placebo, fluvastatin 20 mg plus ezetimibe placebo, fluvastatin 20 mg plus ezetimibe 10 mg, and ezetimibe placebo. Blood samples were collected to measure serum lipids and to determine steady-state pharmacokinetics.

Pharmacodynamic and pharmacokinetic interaction between fenofibrate and ezetimibe.

Objective: The cholesterol absorption inhibitor, ezetimibe, significantly decreases low-density lipoprotein-cholesterol (LDL-C) levels in patients with primary hypercholesterolemia. The pharmacodynamic, pharmacokinetic, and safety profiles of ezetimibe and fenofibrate were evaluated alone and after co-administration in 32 subjects with primary hypercholesterolemia.

Research Design And Methods: This was a randomized, evaluator (single)-blind, placebo-controlled, parallel-group study.