Publications by authors named "Stephen M Ernst"
Article Synopsis
- PMNs play a crucial protective role against Bacillus anthracis infection, but the bacteria can effectively undermine this response, leading to high mortality rates.
- Lethal toxin (LT), a key virulence factor of B. anthracis, is essential for the bacteria's spread in mouse models, but its effects on PMN function remain unclear due to their short lifespan.
- Research shows that LT not only hampers PMN recruitment to inflamed areas but also diminishes their ability to kill B. anthracis, indicating a dual role in weakening the immune response.
Bacillus anthracis can cause inhalational anthrax. Murine inhalational B. anthracis infections have two portals of entry, the nasal mucosa-associated lymphoid tissue (NALT) and the lumen of the lungs.
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