Publications by authors named "Stephen Leahy"
Article Synopsis
- The study investigates whether existing prognostic models for metastatic renal cell carcinoma (RCC) are effective for predicting immediate perioperative outcomes in patients undergoing surgery for RCC with tumor thrombus (TT).
- Analysis was conducted on 55 patients who underwent radical nephrectomy and tumor thrombectomy, with results showing inconsistent associations between preoperative risk factors and perioperative outcomes.
- Specific findings indicated that patients categorized as poorer risk based on different models (IMDC, MSKCC, MDACC, MCC) experienced more postoperative complications, longer hospital stays, and increased intraoperative blood loss, suggesting that established models may have predictive value for these immediate outcomes.
Article Synopsis
- Recent FDA-approved drugs employing RNA interference have been developed to treat liver-specific diseases, particularly benefiting conditions like primary hyperoxaluria type 1.* -
- Primary hyperoxaluria type 1, a disorder caused by enzyme mutations leading to high oxalate levels, historically had limited treatment options, mainly supportive care and transplants.* -
- The approval of the RNA interference drug lumasiran and the potential approval of nedosiran represent a significant advancement in treatment, potentially changing disease outcomes despite some limitations for other types of hyperoxaluria.*
Purpose Of Review: Herein we provide a review of intravascular ultrasound (IVUS) and its ability to assist in the evaluation and surgical management of advanced retroperitoneal, genitourinary tumors.
Recent Findings: Advanced retroperitoneal tumors such as advanced renal cell carcinoma, bulky retroperitoneal lymphadenopathy associated with advanced testicular carcinoma, large adrenal tumors, and retroperitoneal sarcomas can invade, compress, or distort vascular anatomy making surgical resection challenging and high risk. Intravascular ultrasonography is commonly used by vascular and cardiothoracic surgery to provide a real time assessment of vascular invasion, compression, and aberrant anatomy to assist with pre-operative and/or intraoperative decision-making.