Publications by authors named "Stephen Kumar Celestina"
In the fields of pharmacology and life sciences, it is essential to study how prescribed drugs interact with carrier proteins in human serum albumin. The current study has evaluated the binding properties of rhodanine derivative; (z)-2-(4-(5-((3-(3-chlorophenyl)-1-phenyl-1H-pyrazol-4-oxo-2-thioxothiazolidin-3-yl)benzamido)acetic acid (P3CL) on bovine serum albumin (BSA) by biophysical approach. BSA is a homology model of Human serum albumin.
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- Aldose reductase inhibitors are important for preventing diabetes complications, and new derivatives of rhodanine-3-hippuric acid-pyrazole were developed and tested for their effectiveness.
- The synthesized compounds showed strong inhibitory activity against ALR2, with some being significantly more potent than the currently used drug, epalrestat.
- Molecular docking studies indicated that these compounds effectively bind to the active site of ALR2, blocking its activity by disrupting essential interactions in the protein.