Bullous Sweet syndrome associated with an aseptic splenic abscess.

Sweet syndrome is a rare disorder characterized by fever and painful erythematous plaques containing dense dermal neutrophilic infiltrates. Extracutaneous manifestations include alveolitis, sterile osteomyelitis, and arthritis. We present a patient with a bullous presentation of Sweet syndrome who developed an aseptic splenic abscess.

Low-dose acitretin is associated with fewer adverse events than high-dose acitretin in the treatment of psoriasis.

Objective: In practice, lower dose acitretin therapy (25 mg/d) seems to be better tolerated and associated with fewer abnormalities found after laboratory testing. Here we revisit the original phase 3 trials for acitretin to evaluate the evidence for low-dose therapy producing fewer adverse effects than the 50 mg/d dosage.

Design: We retrospectively analyzed pooled data from 2 large pivotal trials, each including a randomized, placebo-controlled, 8-week double-blind phase followed by a 16-week open-label phase.