Publications by authors named "Stephen Kiptoo"
Introduction: In Kenya, patients with breast cancer predominantly present with late-stage disease and experience poor outcomes. To promote early-stage diagnosis, we implemented the Academic Model Providing Access to Healthcare (AMPATH) Breast and Cervical Cancer Control Program (ABCCCP) in Western Kenya.
Objective: The aim of this study was to assess differences between patients presenting to health facilities and health fairs.
Article Synopsis
- A study was conducted with 39 women in Western Kenya who have HIV and are receiving antiretroviral therapy, focusing on HIV-1 RNA levels in the genital tract.
- The research aimed to measure HIV shedding before and after treatment with cryotherapy for cervical lesions.
- Results showed that most HIV shedding occurred before cryotherapy, indicating that the treatment itself was not the main reason for the shedding.
Objectives: Centralized programs have been ineffective in reducing the burden of cervical cancer among Kenyan women. A community-based pilot study was initiated to screen Kenyan women for cervical cancer and to vaccinate their children against human papillomavirus (HPV).
Methods: Women were educated about cervical cancer prevention at community meetings.
Objective: A longitudinal study was conducted among women living with HIV in Kenya to determine if duration of anti-retroviral (ART) usage altered detection and persistence of oncogenic (high-risk) human papillomaviruses (HR-HPV).
Methods: Women living with HIV without cervical dysplasia were enrolled at a cervical cancer screening clinic. Three cervical swabs, HIV viral loads, and CD4 cell counts were obtained at enrollment and at two annual visits.
Objectives: Cervical cancer is caused by persistent infection with oncogenic, or "high-risk" types of human papillomaviruses, and is the most common malignancy in Kenyan women. A longitudinal study was initiated to investigate factors associated with persistent human papillomavirus detection among HIV-infected and HIV-uninfected Kenyan women without evidence of cervical dysplasia.
Methods: Demographic/behavioral data and cervical swabs were collected from HIV-uninfected women (n = 82) and HIV-infected women (n = 101) at enrollment and annually for 2 years.
Article Synopsis
- The study aimed to evaluate the types of HPV infections in HIV-positive and HIV-negative women in western Kenya who were receiving treatment for cervical abnormalities.
- Researchers conducted a prospective observational study and collected data on HPV types, demographics, and HIV status among 175 participants, using methods like visual inspection and cervical swabs.
- Results showed that HIV-positive women had a higher prevalence of low-risk HPV and more high-risk HPV types, with those needing a more extensive procedure (LEEP) being at an even greater risk for multiple high-risk HPV infections compared to those getting cryotherapy.
Background: Cervical cancer is common in Kenyan women. Cofactors in addition to infection with oncogenic human papillomavirus (HPV) are likely to be important in causing cervical cancer, as only a small percentage of HPV-infected women will develop this malignancy. Kenyan women are exposed to dietary aflatoxin, a potent carcinogen and immunosuppressive agent, which may be such a co-factor.
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