Modeling the mechanisms of non-neurogenic dynamic cerebral autoregulation.

Objective: Dynamic cerebral autoregulation (dCA) refers to a collection of mechanisms that act to maintain steady state cerebral blood flow (CBF) near constant despite changes in arterial blood pressure (ABP), but which is known to become impaired in various cerebrovascular diseases. Currently, the mechanisms of dCA and how they are affected in different physiological conditions are poorly understood. The objective of this study was to disentangle the magnitudes and time scales of the myogenic and metabolic responses of dCA, in order to investigate how each mechanism is affected in impaired dCA.

Neurological intervention transition model for dynamic prediction of good outcome in spontaneous subarachnoid haemorrhage.

Deterioration of neurovascular conditions can be rapid in patients with spontaneous subarachnoid haemorrhage (SAH) and often lead to poor clinical outcomes. Therefore, it is crucial to promptly assess and continually track the progression of the disease. This study incorporated baseline clinical conditions, repeatedly measured neurological grades and haematological biomarkers for dynamic outcome prediction in patients with spontaneous SAH.

Oxygen delivery from the cerebral microvasculature to tissue is governed by a single time constant of approximately 6 seconds.

Objective: The cerebral microvasculature plays a key role in the coupling between cerebral blood flow and metabolism. Although experimental imaging techniques now allow for finely detailed measurements of flow and oxygenation, within humans measurements remain confined to a voxel-level scale, of order 1 mm. Mathematical models are thus key in interpreting such data.

The effects of non-linearities on shear stress in periodic flow in axi-symmetric vessels.

In this paper, a power series and a Fourier series approach is used to solve the governing equations of motion in an elastic axi-symmetric vessel, assuming that blood is an incompressible Newtonian fluid. The time averaged flow has shown to be greater than the steady state flow leading to a larger wall shear stress. Oscillations can also be observed, which is not present in the steady state solution.