Effectiveness of bevacizumab step therapy for neovascular age-related macular degeneration.

Objective: To determine the effectiveness of bevacizumab step therapy for neovascular age-related macular degeneration (nAMD) in routine clinical practice.

Methods: In this retrospective case series, eyes initiating treatment for nAMD at an academic medical centre from 2011-2019 were included. Exclusion criteria included previous intravitreal anti-VEGF injections, prior non-cataract intraocular surgery, <1 year of treatment, and not starting on monthly bevacizumab therapy.

Microbial flora and resistance in ophthalmology: a review.

Antibiotic resistance in systemic infection is well-researched and well-publicized. Much less information is available on the resistance of normal ocular microbiome and that of ophthalmic infections. An understanding of the distribution of ocular microorganisms may help us in tailoring our empiric treatment, as well as in choosing effective pre-, peri- and postoperative management, to achieve the best results for patients.

Incidence and risk factors for chronic uveitis following cataract surgery.

Purpose: To determine the incidence of and associated risk factors for uveitis after cataract surgery.

Methods: A total of 17,757 eyes were identified and records of 42 eyes that developed uveitis and 2320 eyes that did not were reviewed. Postsurgical uveitis was defined as persistent inflammation for ≥ 6 months after surgery.

Intraocular T-cell lymphoma due to mycosis fungoides and response to intravitreal methotrexate.

Purpose: To report a case of mycosis fungoides with subsequent intraocular involvement and good response to intravitreal methotrexate.

Design: Case report.

Methods: Retrospective chart review.

Critical appraisal of ophthalmic ketorolac in treatment of pain and inflammation following cataract surgery.

Background: The purpose of this review was to provide a critical appraisal of the literature supporting the efficacy of ophthalmic ketorolac (Acuvail(®)) in the treatment of pain and inflammation after cataract surgery.

Methods: Literature search and expert opinion of the authors.

Results: Recent studies indicate greater intraocular drug levels in the anterior chamber and iris-ciliary body after topical application of Acuvail in comparison with older formulations of ketorolac.

Long-term trends in intraocular pressure after pars plana vitrectomy.

Purpose: To evaluate the effect of vitrectomy on intraocular pressure (IOP).

Methods: Retrospective cohort study. Medical records of 101 eyes of 101 patients undergoing nonemergent vitrectomy were reviewed for rates of open-angle glaucoma, increased IOP of >4 mmHg from baseline, change in IOP from baseline, and cataract formation.

Long-term stability and visual outcomes of a single-piece, foldable, acrylic intraocular lens for scleral fixation.

Purpose: To report long-term visual outcomes and complications of a new foldable, one-piece, acrylic posterior chamber intraocular lens with closed-loop haptics (C-flex, Rayner, UK) for scleral fixation.

Study Design: Retrospective interventional case series of 29 eyes of 29 patients who underwent scleral fixation with the C-flex intraocular lens in the absence of capsular support.

Methods: Review of 29 consecutive cases from January 2001 to December 2005 in which scleral fixation was performed with the C-flex intraocular lens.