Publications by authors named "Stephen J Roper"
Article Synopsis
- Embryonic stem cells maintain a dynamic equilibrium of distinct functional states by expressing various pluripotency factors and reversible histone modifications.
- The ADP-ribosyltransferases Parp1 and Parp7 are crucial for preserving this pluripotent state by protecting essential pluripotency genes from being repressed.
- Without Parp1 or Parp7, or if their activity is inhibited, embryonic stem cells lose their pluripotency and are more likely to differentiate.
Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth.
Proc Natl Acad Sci U S A
March 2011
The mammalian fetus represents a semiallograft within the maternal uterus yet is not rejected. This situation is particularly pronounced in species with a hemochorial type of placentation, such as humans and rodents, where maternal tissues and blood are in direct contact with fetal trophoblast and thus potentially with paternal antigens. The main polymorphic antigens responsible for graft rejection are MHC antigens.
View Article and Find Full Text PDFEMSY interacts directly with BRCA2 and links the BRCA2 pathway to sporadic breast and ovarian cancer. It also interacts with BS69 and HP1b, both of which are involved in chromatin remodelling, and with NIF-1 and DBC-1 in the regulation of nuclear receptor-mediated transcription. Here we investigate the function of EMSY during amphibian development, and in doing so provide the first loss-of-function analysis of this protein.
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