Publications by authors named "Stephen J Blakemore"
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Synopsis of recent research by authors named "Stephen J Blakemore"
- Stephen J Blakemore's recent research primarily focuses on the development and clinical evaluation of small-molecule inhibitors targeting histone modifying enzymes, specifically DOT1L and EZH2, in various hematologic malignancies, highlighting both safety and efficacy in adult patients.
- His studies, such as those on pinometostat and tazemetostat, aim to understand treatment-emergent resistance mechanisms and the pharmacodynamics of these inhibitors, ultimately improving therapeutic strategies for challenging cancers like acute leukemia and non-Hodgkin lymphoma.
- Blakemore has also explored the role of the NEDD8-activating enzyme in cancer treatment, demonstrating anti-tumor potential of the inhibitor pevonedistat in melanoma and hematologic disorders, offering insights into proteasomal protein degradation pathways in oncology.
