Publications by authors named "Stephen Harasimchuk"

Background And Objectives: Stereoelectroencephalography (SEEG) is an important method for invasive monitoring to establish surgical candidacy in approximately half of refractory epilepsy patients. Identifying factors affecting lead placement can mitigate potential surgical risks. This study applies multivariate analyses to identify perioperative factors affecting stereotactic electrode placement.

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Article Synopsis
  • A new noninvasive fiducial attachment for stereotactic registration in sEEG was created and validated, eliminating the need for extra scalp surgery while increasing reference points.
  • The study involved 25 patients, and measurements showed an average registration error of just 0.77 mm without significant complications.
  • Results indicated low trajectory error for electrode placement, suggesting that the device is safe and effective for improving precision in epilepsy monitoring.
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Article Synopsis
  • - Radiofrequency thermocoagulation (RFTC) has been used since 2004 as a safe method for creating lesions to treat epilepsy, but is not widely practiced in the U.S. due to lack of FDA-approved technologies for in situ sEEG electrodes.
  • - A case study of a young woman with drug-resistant temporal lobe epilepsy shows successful seizure freedom for 18 months following sEEG-guided RFTC performed with a specialized probe, despite the procedure's primary intent being diagnostic.
  • - The authors emphasize the limited application of this technique in the U.S., advocating for it as a temporary solution while stressing the urgent need for new FDA-approved devices to safely perform RFTC with sEEG electrodes.
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Invasive neuromonitoring is an important component of presurgical workup and seizure onset zone localization in patients with epilepsy being considered for surgical resection. In the United States, intraparenchymal stereoelectroencephalography (SEEG) electrodes have been replacing subdural grid electrodes for most cases, following a trend that has already matured in Europe. The use of robotic assistance has been shown to improve operative times and accuracy in SEEG electrode placement, as users benefit from the embedded planning software as well as the efficiency and accuracy of the robotic arm.

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