Publications by authors named "Stephen G Kay"
Article Synopsis
- Early administration of anti-anaerobic antibiotics in critically ill patients is linked to lower survival rates, increased risk of infections, and reduced VAP-free survival.
- The study included over 3000 patients and showed significant changes in gut microbiota, with a shift towards Enterobacteriaceae, which are associated with respiratory infections.
- Murine models confirmed that depletion of anaerobes due to these antibiotics heightened vulnerability to pneumonia and increased the lethality of non-infectious conditions like hyperoxia.
Background: Whereas data from the pre-pandemic era have demonstrated that tracheostomy can accelerate liberation from the ventilator, reduce need for sedation, and facilitate rehabilitation, concerns for healthcare worker safety have led to disagreement on tracheostomy placement in COVID-19 patients. Data on COVID-19 patients undergoing tracheostomy may inform best practices. Thus, we report a retrospective institutional cohort experience with tracheostomy in ventilated patients with COVID-19, examining associations between time to tracheostomy and duration of mechanical ventilation in relation to patient characteristics, clinical course, and survival.
View Article and Find Full Text PDFPatients with severe coronavirus disease (COVID-19) meet clinical criteria for the acute respiratory distress syndrome (ARDS), yet early reports suggested they differ physiologically and clinically from patients with non-COVID-19 ARDS, prompting treatment recommendations that deviate from standard evidence-based practices for ARDS. To compare respiratory physiology, clinical outcomes, and extrapulmonary clinical features of severe COVID-19 with non-COVID-19 ARDS. We performed a retrospective cohort study, comparing 130 consecutive mechanically ventilated patients with severe COVID-19 with 382 consecutive mechanically ventilated patients with non-COVID-19 ARDS.
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