Publications by authors named "Stephen E Abbott"
Objective: The aim of the study is to determine the prevalence of high-risk human papillomavirus (hrHPV) genotypes in men who have sex with other men and are living with HIV and the factors associated with anal high-grade squamous intraepithelial lesions (HSIL).
Methods: Anal swabs were collected for hrHPV genotyping from a cross-sectional group ( N = 163) of eligible men who have sex with other men and are living with HIV attending a high-resolution anoscopy clinic. Persistent hrHPV infections were studied in a longitudinal subset ( n = 37).
Article Synopsis
- The study aimed to assess if a positive OncoE6 Anal Test result could predict high-grade squamous intraepithelial lesion (HSIL) in adult men who have sex with men and are living with HIV.
- 277 men enrolled, with 79.1% undergoing biopsies; 37% of these biopsies showed HSIL.
- The OncoE6 Anal Test showed high specificity (97.83%) but low sensitivity (8.64%), suggesting it could complement the anal Pap test for efficient triage of patients at higher risk for anal cancer.
Importance: In the US, incidence of and mortality due to anal carcinoma are rising faster than for most other cancers. Identifying populations who have a higher risk of developing anal cancers is critical to target preventive interventions.
Objective: To assess the risk of developing anal carcinoma in adults living with HIV who have a history of anogenital warts.