Publications by authors named "Stephen Chih"
Article Synopsis
- Ferroptosis is a special type of cell death that relies on iron and happens when fats in cells become damaged, which is important for fighting diseases like cancer.
- Researchers are interested in using ferroptosis to help treat cancer cells, especially those that don’t respond to regular treatments like chemotherapy.
- The review talks about recent studies on how to make gliomas, a type of brain tumor, more sensitive to ferroptosis, while also noting that this process can sometimes help tumors grow, making treatment tricky.
Article Synopsis
- Necrosis in solid tumors, particularly glioblastoma, is linked to a poor prognosis, and neutrophils play a crucial role in its development by inducing tumor cell death through specialized granules.
- Research revealed that statins can block the transfer of these neutrophilic granules, protecting tumor cells from death, suggesting a potential therapeutic pathway.
- The study identified a process where neutrophils are engulfed by tumor cells via specific adhesion mechanisms, facilitating the transfer of harmful contents, and targeting this process could improve survival rates in glioblastoma models.
Tumor necrosis is a poor prognostic marker in glioblastoma (GBM) and a variety of other solid cancers. Accumulating evidence supports that necrosis could facilitate tumor progression and resistance to therapeutics. GBM necrosis is typically first detected by magnetic resonance imaging (MRI), after prominent necrosis has already formed.
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- Monomethyl auristatin E (MMAE) is an effective anti-cancer agent used in antibody-drug conjugates (ADCs) but is associated with peripheral neuropathy, often leading to treatment complications.
- MMAE’s neurotoxic effects stem from its non-specific uptake in peripheral nerves, disrupting microtubules (MTs) and causing neurodegeneration through its binding and distortion of MT structures.
- The study shows that MMAE severely impairs MT dynamics and axonal transport, highlighting the need to understand drug-specific interactions to manage adverse effects like peripheral neuropathy.
Tumor necrosis commonly exists and predicts poor prognoses in many cancers. Although it is thought to result from chronic ischemia, the underlying nature and mechanisms driving the involved cell death remain obscure. Here, we show that necrosis in glioblastoma (GBM) involves neutrophil-triggered ferroptosis.
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