The Roadmap to Integrate Diversity, Equity, and Inclusion in Hematology Clinical Trials: An American Society of Hematology Initiative.

Clinical trial design for classical hematologic diseases is difficult because samples sizes are often small and not representative of the disease population. ASH initiated a Roadmap project to identify barriers and make progress to integrate diversity, equity, and inclusion into trial design and conduct. Focus groups of international experts from across the clinical trial ecosystem were conducted.

Strong π-stacking causes unusually large anisotropic thermal expansion and thermochromism.

π-stacking in ground-state dimers/trimers/tetramers of -butoxyphenyl(naphthalene)diimide (BNDI) exceeds 50 kcal ⋅ mol in strength, drastically surpassing that for the [pyrene] excimer (∼30 kcal ⋅ mol; formal bond order = 1) and similar to other weak-to-moderate classical covalent bonds. Cooperative π-stacking in triclinic (BNDI-T) and monoclinic (BNDI-M) polymorphs effects unusually large linear thermal expansion coefficients (α , α , α , β) of (452, -16.8, -154, 273) × 10 ⋅ K and (70.

Spontaneous right-sided microcavitations in a healthy adult.

Unlabelled: Spontaneous echo contrast (SEC) is frequently observed in patients with structural and functional cardiovascular abnormalities. Literature describes cases of SEC either from agglutination of red blood cells and plasma proteins or from microcavitations. SEC secondary to the former is an independent predictor of future thromboembolic events and is most commonly observed in the left atrium or left atrial appendage.

Platypnea-Orthodeoxia in Patients on Hemodialysis: A New Approach to Its Pathophysiology and Implications for Treatment.

Platypnea-orthodeoxia is a poorly understood clinical syndrome resulting in dyspnea and hypoxemia in the upright position, which diminishes with recumbency. Recognition of the disease is limited by its low prevalence and decreased awareness among clinicians. However, understanding the disease, its pathophysiology, its clinical presentation, and the possible therapeutic options is vital in the management of these patients.

Incidence and characteristics of patients presenting with acute myocardial infarction and non-obstructive coronary artery disease.

Objectives: This study aimed to characterize the etiologies of patients presenting with myocardial infarction (MI) and found to have non-obstructive coronary artery disease (NOCAD) and compare risk factors and in-hospital mortality to those with obstructive coronary artery disease (CAD).

Background: Patients presenting with an MI are often found to have NOCAD defined as less than 50% luminal diameter reduction by visual estimation on coronary angiography.

Methods: This study is a retrospective analysis of a total of 2,038 patients that presented to NorthShore University HealthSystem with MI and underwent coronary angiography from 2010 to 2013.