Intra-articular Treatment of Osteoarthritis with Diclofenac-Conjugated Polymer Reduces Inflammation and Pain.

The most common treatment for osteoarthritis is daily oral administration of a nonsteroidal anti-inflammatory drug such as diclofenac. This daily dosage regime is often associated with severe side effects. In this study, we explored the potential of utilizing a high molecular weight cross-linked polyurethane polymer covalently linked to diclofenac () for intra-articular administration.

Experimental investigation of the piano hammer-string interaction.

Experimental techniques for investigating the piano hammer-string interaction are described. It is argued that the accuracy, consistency, and scope of conclusions of previous studies can be compromised by limitations of the conventional methods relating to key inputs; physical distortion; numerical distortion, particularly when differentiation or integration of measured signals is used to derive primary response variables; contact identification; and synchronization issues. These problems are discussed, and experimental methods that have been devised to avoid them are described and illustrated by detailed results from a study of the hammer-string interaction in a vertical piano.

Total synthesis of the proposed structure of 8-deshydroxyajudazol A: a modified approach to 2,4-disubstituted oxazoles.

The total synthesis of the proposed structure for the minor myxobacterial metabolite 8-deshydroxyajudazol A (3) is described. The isochromanone moiety present in the eastern fragment was constructed by an intramolecular-Diels-Alder (IMDA). Difficulties were encountered with the formation of the 2,4-disubstituted oxazole, so this was synthesized via a modified approach.

Total synthesis of 8-deshydroxyajudazol B.

The total synthesis of a stereoisomer of 8-deshydroxyajudazol B (4), the putative biosynthetic intermediate of the ajudazols A (1) and B (2), is described. The key steps in the synthesis included an intramolecular Diels-Alder (IMDA) reaction to secure the isochromanone fragment, a novel selective acylation/O,N-shift to give a hydroxyamide which was cyclized to the oxazole and a high yielding Sonogashira coupling to form the C18-C19 bond. Partial alkyne reduction then afforded the target 4.

Synthesis and redox properties of triarylmethane dye cation salts of anions [M6O19]2- (M = Mo, W).

Four salts have been isolated combining the triarylmethane dye cations pararosaniline (PR(+)) and crystal violet (CV(+)) with the hexametalates [M(6)O(19)](2-) (M = Mo, W). A new hexatungstic acid H(2)[W(6)O(19)]·4dma (dma = dimethylacetamide) was isolated and is a useful synthon for hexatungstate salts. Single-crystal X-ray diffraction confirmed the presence of PR(+) and [Mo(6)O(19)](2-) ions in [PR](2)[Mo(6)O(19)]·6dmf (dmf = dimethylformamide).

Modeling the dynamics of a compliant piano action mechanism impacting an elastic stiff string.

A realistic model of the piano hammer-string interaction must treat the action mechanism and string as a single system. In this paper an elastic stiff string model is integrated with a dynamic model of a compliant action mechanism with flexible hammer shank. Action components represented as rotating bodies interact through felt-lined interfaces for which a specialized contact model with hysteretic damping and tangential friction was developed.

Modeling the dynamics of a vibrating string with a finite distributed unilateral constraint: application to the sitar.

The free vibration response of an ideal string impacting a distributed parabolic obstacle located at its boundary has been analyzed, the goal being to understand and simulate a sitar string. The portion of the string in contact with the obstacle is governed by a different partial differential equation (PDE) from the free portion represented by the classical string equation. These two PDEs and corresponding boundary conditions, along with the transversality condition that governs the dynamics of the moving boundary, are obtained using Hamilton's principle.

Previous feeding level influences plateau heat production following a 24 h fast in growing pigs.

Factorial approaches to estimate energy requirements of growing pigs require estimation of maintenance energy requirements. Heat production (HP) during fasting (FHP) may provide an estimate of maintenance energy requirements. Six barrows were used to determine effects of feeding level on components of HP, including extrapolated plateau HP following a 24 h fast (FHPp).