Publications by Stephen Bela Kovacs

Publications by authors named "Stephen Bela Kovacs"

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Caspase-1 activates gasdermin A in non-mammals.

Zachary Paul Billman Stephen Bela Kovacs Bo Wei Kidong Kang Ousmane H Cissé

Elife

March 2024

Gasdermins oligomerize to form pores in the cell membrane, causing regulated lytic cell death called pyroptosis. Mammals encode five gasdermins that can trigger pyroptosis: GSDMA, B, C, D, and E. Caspase and granzyme proteases cleave the linker regions of and activate GSDMB, C, D, and E, but no endogenous activation pathways are yet known for GSDMA.

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