Harmonic Motion Imaging-Guided Focused Ultrasound Ablation: Comparison of Three Focused Ultrasound Interference Filtering Methods.

Objective: Harmonic motion imaging (HMI) is an acoustic radiation force-based elasticity imaging technique, which can be used to monitor changes in tissue mechanical properties caused by focused ultrasound (FUS)-induced thermal ablation. In conventional HMI, the amplitude-modulated FUS sequence and imaging pulse are transmitted simultaneously. With this method, the high-amplitude FUS signal must be separated from the imaging data for tissue displacement estimation.

Asynchronous release sites align with NMDA receptors in mouse hippocampal synapses.

Neurotransmitter is released synchronously and asynchronously following an action potential. Our recent study indicates that the release sites of these two phases are segregated within an active zone, with asynchronous release sites enriched near the center in mouse hippocampal synapses. Here we demonstrate that synchronous and asynchronous release sites are aligned with AMPA receptor and NMDA receptor clusters, respectively.