Publications by authors named "Stephanie Walton-Filipczak"
Caspases and poly (ADP-ribose) polymerase 1 (PARP1) have been shown to promote influenza A virus (IAV) replication. However, the relative importance and molecular mechanisms of specific caspases and their downstream substrate PARP1 in regulating viral replication in airway epithelial cells (AECs) remains incompletely elucidated. Here, we targeted caspase 2, 3, 6, and PARP1 using specific inhibitors to compare their role in promoting IAV replication.
View Article and Find Full Text PDFThe role of transcriptional regulator ten-eleven translocation methylcytosine dioxygenease 1 (TET1) has not been well characterized in lung cancer. Here we show that TET1 is overexpressed in adenocarcinoma and squamous cell carcinomas. TET1 knockdown reduced cell growth and and induced transcriptome reprogramming independent of its demethylating activity to affect key cancer signaling pathways.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how different HDM (house dust mite) exposure patterns affect inflammation in a mouse model of asthma, comparing continuous exposure to intermittent exposure.
- Results showed that intermittent sensitization leads to significantly greater levels of inflammation and mucus production compared to continuous exposure, with the highest effects observed at certain dosages of HDM.
- The findings indicate that the sensitization method can greatly influence immune responses, suggesting careful consideration is needed in designing future asthma research using mouse models.