Variable and Biological Effects of Cerium Oxide Nanoparticle Formulations.

Cerium oxide nanoparticles (CeNPs) exhibit redox capacity with efficacy in disease models of oxidative stress. Here we compare, in parallel, three CeNP formulations with distinct chemical stabilizers and size. assays revealed antioxidant activity from all the CeNPs, but when administered to mice with a reactive oxygen species (ROS) mediated model of multiple sclerosis, only custom-synthesized Cerion NRx (CNRx) citrate-EDTA stabilized CeNPs provided protection against disease.