Is Critical for AII Amacrine Cell Production: Selective Bipolar Cell Dependencies and Diminished ERG.

The nuclear factor one (NFI) transcription factor genes , , and are all enriched in late-stage retinal progenitor cells, and their loss has been shown to retain these progenitors at the expense of later-generated retinal cell types. Whether they play any role in the specification of those later-generated fates is unknown, but the expression of one of these, , in a specific amacrine cell type may intimate such a role. Here, conditional knockout (-CKO) mice (both sexes) were assessed, finding a massive and largely selective absence of AII amacrine cells.