Publications by authors named "Stephanie Stypa"
Article Synopsis
- Ulcerative colitis is a common condition in Canada, necessitating the exploration of affordable treatment options; the study evaluates the cost-effectiveness of the newly approved subcutaneous vedolizumab compared to various other therapies from a Canadian healthcare payer's perspective.* -
- A decision tree/Markov model was used to analyze costs, quality-adjusted life-years (QALYs), and treatment effectiveness for vedolizumab SC against several established therapies, accounting for uncertainties and varying treatment scenarios.* -
- Results indicated that while conventional therapy was the most cost-effective overall, vedolizumab SC was a cost-effective and leading option when compared to other advanced treatments, offering significant savings and achieving the highest QALYs among
Objective: Salsalate is a prodrug of salicylate that lowers blood glucose in people with type 2 diabetes. AMP-activated protein kinase (AMPK) is an αβγ heterotrimer which inhibits macrophage inflammation and the synthesis of fatty acids and cholesterol in the liver through phosphorylation of acetyl-CoA carboxylase (ACC) and HMG-CoA reductase (HMGCR), respectively. Salicylate binds to and activates AMPKβ1-containing heterotrimers that are highly expressed in both macrophages and liver, but the potential importance of AMPK and ability of salsalate to reduce atherosclerosis have not been evaluated.
View Article and Find Full Text PDFAtherosclerosis stems from imbalances in lipid metabolism and leads to maladaptive inflammatory responses. The AMP-activated protein kinase (Ampk) is a highly conserved serine/threonine kinase that regulates many aspects of lipid and energy metabolism, although its specific role in controlling macrophage cholesterol homeostasis remains unclear. We sought to address this question by testing the effects of direct Ampk activators in primary bone marrow-derived macrophages from Ampk β1-deficient (β1(-/-)) mice.
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