Publications by authors named "Stephanie Soriano-Cruz"
Article Synopsis
- The generation of neurons in the central nervous system involves radial glia, which are mitotic progenitors that rapidly proliferate to form a dense neurepithelium and produce different neuronal sub-types.
- Molecular mechanisms behind this process are not well understood, but a family of enzymes called GDE proteins, including GDE6, play a role in neural development.
- Research shows that overexpression of GDE6 leads to neural tube hyperplasia, abnormal neurepithelium growth, and a decrease in the production of motor neurons, indicating its important role in regulating radial glia and neurogenesis alongside GDE2.
α-Synuclein (αSyn) aggregation in Lewy bodies and neurites defines both familial and 'sporadic' Parkinson's disease. We previously identified α-helically folded αSyn tetramers, in addition to the long-known unfolded monomers, in normal cells. PD-causing αSyn mutations decrease the tetramer:monomer (T:M) ratio, associated with αSyn hyperphosphorylation and cytotoxicity in neurons and a motor syndrome of tremor and gait deficits in transgenic mice that responds in part to L-DOPA.
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