Publications by authors named "Stephanie Rehfeldt"

Article Synopsis
  • Luteolin-7-O-glucoside (Lut7) shows potential benefits for the central nervous system by reducing inflammation, oxidative stress, and neuronal damage.
  • In lab tests, Lut7 improved cell viability in both undifferentiated and differentiated SH-SY5Y cells exposed to neurotoxic conditions and demonstrated high antioxidant activity compared to synthetic alternatives.
  • Lut7 treatment also modulated inflammatory cytokines in immune cells, suggesting its neuroprotective effects may warrant further investigation for treating neurodegenerative diseases.
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Article Synopsis
  • Current treatments for neurodegenerative diseases mainly relieve symptoms but do not slow disease progression, highlighting the need for effective therapies.
  • The study investigates the compound FMU200, which inhibits JNK3, for its neuroprotective, anti-inflammatory, and antioxidant properties using cell lines SH-SY5Y and RAW264.7.
  • Results indicate that FMU200 significantly reduces cell damage from neurotoxins, decreases apoptosis, lowers reactive oxygen species, restores mitochondrial function, and diminishes inflammatory responses, suggesting its potential as a treatment option for neurodegenerative disorders.
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The treatment of Parkinson´s disease (PD) has benefited from significant advances resulting from the increasing research efforts focused on new therapeutics. However, the current treatments for PD are mostly symptomatic, alleviating disease symptoms without reversing or retarding disease progression. Thus, it is critical to find new molecules that can result in more effective treatments.

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Parkinsons Disease (PD) is the second most common neurodegenerative disease worldwide, and is characterized by a progressive degeneration of dopaminergic neurons. Without an effective treatment, it is crucial to find new therapeutic options to fight the neurodegenerative process, which may arise from marine resources. Accordingly, the goal of the present work was to evaluate the ability of the monoterpenoid lactone Loliolide, isolated from the green seaweed , to prevent neurological cell death mediated by the neurotoxin 6-hydroxydopamine (6-OHDA) on SH-SY5Y cells and their anti-inflammatory effects in RAW 264.

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