Gastric electrical stimulation has an immediate antiemetic effect in patients with gastroparesis.

Background: Electrical stimulation has been successfully employed to treat diseases involving electro-pathology in the heart, skeletal muscles, and the brain, but not in the GI tract.

Aim: This study examined the clinical feasibility and efficacy of GES in treating patients with severe gastroparesis.

Methods: Nausea, vomiting, GEA, and liquid and solid gastric emptying were monitored in eleven patients with refractory gastroparesis at baseline and after one week of continuous electrical stimulation administered at 12 cycles/min.