Publications by authors named "Stephanie Pagliuca"
Article Synopsis
- Doctors often use certain medicines to treat high blood pressure, but older people can have more problems with these meds.
- A 90-year-old man took one of these medications and ended up having a fall and some unusual lab results, meaning his body wasn't handling the medicine well.
- The situation showed that even though these medicines are recommended, they might not be safe for older people who could get sick from them.
In situ hybridization assay-based small molecule screening in zebrafish.
Curr Protoc Chem Biol
June 2012
In vitro biochemical and cell-based small molecule screens have been widely used to identify compounds that target specific signaling pathways. But the identified compounds frequently fail at the animal testing stage, largely due to the in vivo absorption, metabolism and toxicity of chemicals. Zebrafish has recently emerged as a vertebrate whole organism model for small molecule screening.
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