Publications by authors named "Stephanie Morgant"
Article Synopsis
- Variants in the PRSS1 and PRSS2 genes are linked to chronic pancreatitis (CP), prompting research into whether a deletion variant affecting two trypsinogen pseudogenes (PRSS3P2 and TRY7) might influence CP risk.
- A study analyzed this deletion in over 4,000 participants from different countries and found that it is associated with a protective effect against CP, especially in French, German, and Japanese populations.
- The research suggests that the deletion enhances the function of remaining genes, leading to regulated PRSS2 expression, which could be crucial in understanding CP susceptibility.
Background: Endoscopic ultrasound (EUS) is a key imaging technique in gastric cancer (GC). The aim of this study was to evaluate the performance of EUS in the staging of parietal and lymph node involvement in linitis plastica (LP) compared to "classical" GC.
Methods: A retrospective multicentric French study was conducted on patients with no metastatic LP and operated by gastrectomy.
Article Synopsis
- The study evaluated the effectiveness of CT scans in staging gastric linitis plastica, a type of gastric adenocarcinoma.
- Results showed that patients with linitis plastica had younger diagnoses, more advanced cancer stages, and complications like undiagnosed peritoneal carcinomatosis, which impacted surgical outcomes.
- CT scans exhibited lower sensitivity in detecting lymph node and T3-T4 parietal invasions in the linitis plastica group compared to controls, highlighting its limitations for low-volume peritoneal carcinomatosis despite being crucial for preoperative evaluations.