Publications by authors named "Stephanie Monday"
An individual's immune function, susceptibility to infection, and response to immunosuppressive therapy are influenced in part by his/her T cell maturation state. Although childhood is the most dynamic period of immune maturation, scant information regarding the variability of T cell maturation in children with renal disease is available. In this study, we compared the T cell phenotype in children with renal failure (n=80) with that in healthy children (n=20) using multiparameter flow cytometry to detect markers of T cell maturation, exhaustion, and senescence known to influence immune function.
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- The study investigates how latent viral infections (like MHV68) impact immune responses and lead to faster rejection of transplanted skin in rodents, especially when immune signals are blocked.
- MHV68 infection causes changes in immune cell behavior, creating a unique condition where certain T cells grow but lose some critical activation signals, speeding up the rejection of skin grafts.
- When combining specific blocking strategies (anti-LFA-1/anti-VLA-4 with anti-CD154), both infected and non-infected rodents showed long-term acceptance of skin grafts, but the right combination is crucial for infected animals for better results.