Publications by authors named "Stephanie Milczarek"
Article Synopsis
- Tumorigenesis is associated with increased mitochondrial reactive oxygen species (mROS), prompting cancer cells to enhance their antioxidant defenses and redox signaling pathways.
- *Thiostrepton (TS) targets mitochondrial peroxiredoxin 3 (PRX3), an enzyme that detoxifies hydrogen peroxide, by modifying its key cysteine residues, leading to PRX3 inactivation.
- *Studies show that PRX3 expression and mROS levels correlate with sensitivity to TS in malignant mesothelioma, indicating that PRX3's structural properties make it a promising target for therapies that increase prooxidants in cancer cells.
Mitochondria are strategically trafficked throughout the cell by the action of microtubule motors, the actin cytoskeleton and adapter proteins. The intracellular positioning of mitochondria supports subcellular levels of ATP, Ca and reactive oxygen species (ROS, i.e.
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