Publications by authors named "Stephanie Maher"
Article Synopsis
- Neurotrophic receptor tyrosine kinases TrkA, TrkB, and TrkC play different roles in neuroblastoma, a childhood cancer, with TrkA linked to better outcomes and lower disease stages, while TrkB is often found in more aggressive forms associated with MYCN amplification.
- This study used advanced mass spectrometry to analyze proteins and phosphoproteins in neuroblastoma cells, revealing substantial data (4,907 proteins, 16,744 phosphosites) that highlights the distinct signaling of these Trk receptors and their interaction with MYCN status.
- The findings could lead to better understanding and treatment strategies for neuroblastoma by clarifying how different Trk receptors influence the
Article Synopsis
- cSTAR is a new method for analyzing and influencing cell state transitions, helping researchers understand how cells change from one type to another.
- It utilizes omics data to create detailed models that depict cell behavior and guides interventions for controlling cell fate decisions.
- Successful application of cSTAR has shown strong correlations with experimental outcomes and offers insights into cellular development, making it a promising tool for future therapies.
Genes encoding Wnt ligands are crucial in body patterning and are highly conserved among metazoans. Given their conservation at the protein-coding level, it is likely that changes in where and when these genes are active are important in generating evolutionary variations. However, we lack detailed knowledge about how their deployment has diverged.
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