Publications by authors named "Stephanie M Swedik"
Article Synopsis
- Subunit or inactivated vaccines are commonly used but often less effective than live vaccines, necessitating boosters and adjuvants for better immune responses.
- Research has shown that directly linking adjuvants to antigens can enhance vaccine effectiveness, as seen in the development of an inactivated influenza A vaccine combined with the adjuvant resiquimod (R848).
- The study found that varying the crosslinker used to connect R848 to the virus influenced how well the vaccine stimulated immune response, affecting cytokine production and antibody levels in both lab and mouse model experiments.
Tightly regulated communication between the gastrointestinal epithelium and immune cells in the underlying lamina propria is critical for immune homeostasis and inflammation. IL-17C, produced by epithelial cells after exposure to inflammatory stimuli, facilitates cell-to-cell communication by promoting inflammatory responses in Th17 cells. In this study, we demonstrate that Th17-derived cytokines TNF-α, IL-17A, and IL-22 synergistically enhance IL-17C expression in both human-transformed colonic epithelial cell lines and primary non-inflammatory bowel disease colonic epithelial spheroids.
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