Publications by authors named "Stephanie M Ryan"

Article Synopsis
  • Researchers explored using the immunomodulatory properties of helminth proteins, specifically by creating a library of recombinant proteins from hookworms.
  • They identified 20 proteins that showed significant anti-inflammatory effects in a mouse model, which could lead to novel treatments for IBD and other inflammatory diseases.
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Parasitic helminths have coevolved with humans over millennia, intricately refining and developing an array of mechanisms to suppress or skew the host's immune system, thereby promoting their long-term survival. Some helminths, such as hookworms, cause little to no overt pathology when present in modest numbers and may even confer benefits to their human host. To exploit this evolutionary phenomenon, clinical trials of human helminth infection have been established and assessed for safety and efficacy for a range of immune dysfunction diseases and have yielded mixed outcomes.

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