Publications by authors named "Stephanie M Lanasa"
Presence of pores and hydrogel composition influence tensile properties of scaffolds fabricated from well-defined sphere templates.
J Biomed Mater Res B Appl Biomater
February 2011
Article Synopsis
- Sphere templating creates porous polymer scaffolds ideal for tissue engineering, enhancing cell seeding and nutrient transport.
- The study investigates how pore size and polymer type affect the mechanical properties of hydrogels made from PEG and pHEMA, finding that more pores lead to lower stiffness but higher strain capacity.
- Results indicate that smaller pores promote better cell adhesion, highlighting the importance of tailoring pore characteristics and polymer chemistry for optimizing scaffold performance.
This study assessed the role of immobilized cell adhesion moieties on controlling the cellular attachment, adhesion and phenotype of cardiac muscle cells towards developing scaffolds for cardiac muscle tissue engineering. Collagen I, laminin and the cell-adhesive oligopeptide, arginine-glycine-aspartic acid (RGD) at concentrations of 0.5 and 5 mM were covalently bound to flexible two-dimensional hydrogels.
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