Conversion of substrate analogs suggests a Michael cyclization in iridoid biosynthesis.

The core structure of the iridoid monoterpenes is formed by a unique cyclization reaction. The enzyme that catalyzes this reaction, iridoid synthase, is mechanistically distinct from other terpene cyclases. Here we describe the synthesis of two substrate analogs to probe the mechanism of iridoid synthase.

Assessment of adherence in elderly patients in primary care.

Objective: To identify the prevalence of non-adherence to drug therapy for elderly patients in primary care in Blumenau, SC, Brazil.

Methods: This is a cross-sectional, population-based epidemiological study. A randomly selected sample of users who attended the pharmacies of 14 units of primary healthcare answered the questionnaire's study variables.