Publications by authors named "Stephanie Legrand"
Article Synopsis
- Diminished ovarian reserve (DOR) and primary ovarian insufficiency (POI) significantly contribute to female infertility, with a recent study finding a genetic cause in 29.3% of POI cases.
- A prospective study of 120 patients with unexplained DOR revealed a 24.2% diagnostic yield using advanced sequencing technology to identify genes related to various biological pathways.
- Findings indicated that impaired oocyte quality is linked to meiosis/DNA repair genes, and the study supports the need for genetic testing as a routine part of infertility diagnosis and a potential predictor for progression to POI.
Article Synopsis
- Primary Ovarian Insufficiency (POI) affects 1-3.7% of women under 40, leading to issues like infertility and reduced lifespan, with many causes remaining unidentified; recent studies are exploring genetic links to POI through a large cohort of patients.* -
- The research included 375 patients and uncovered a 29.3% success rate for clinical genetic diagnosis of POI, discovering new pathogenic genes and pathways previously unlinked to POI, while confirming the role of several known genes associated with cancer susceptibility and other genetic disorders.* -
- This genetic understanding enables personalized medicine approaches, which aim to prevent or treat related health issues, predict ovarian reserve, and identify candidates for innovative therapies like in vitro
The aim of this work was to prove that solid-phase microextraction coupled with gas chromatography could be used for the determination and quantification of residual solvents in drugs. Four solvents were selected for the experiments: ethanol, cyclohexane, triethylamine and pyridine, together with a model powdered drug substance. Several kinds of fibers, together with the extraction mode, were evaluated to determine the most appropriate one for the simultaneous extraction of the four solvents.
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