Data pipeline for managing field experiments.

As agricultural and environmental research projects become more complex, increasingly with multiple outcomes, the demand for technical support with experiment management and data handling has also increased. Interactive visualisation solutions are user-friendly and provide direct information to facilitate decision making with timely data interpretation. Existing off-the-shelf tools can be expensive and require a specialist to conduct the development of visualisation solutions.

Sustained activation of c-Jun N-terminal and extracellular signal-regulated kinases in port-wine stain blood vessels.

Background: Port-wine stain (PWS) is a congenital, progressive vascular malformation but the pathogenesis remains incompletely understood.

Objective: We sought to investigate the activation status of various kinases, including extracellular signal-regulated kinase, c-Jun N-terminal kinase, AKT, phosphatidylinositol 3-kinase, P70 ribosomal S6 kinase, and phosphoinositide phospholipase C γ subunit, in PWS biopsy tissues.

Methods: Immunohistochemistry was performed on 19 skin biopsy samples from 11 patients with PWS.

Bronchoscopic intervention obviates the need for continued mechanical ventilation in patients with airway obstruction and respiratory failure from inoperable non-small-cell lung cancer.

Background: Patients with advanced non-small-cell lung cancer (NSCLC) and acute respiratory failure (ARF) from central airway obstruction (CAO) may be offered end-of-life care rather than intensive care treatment and palliative bronchoscopic intervention.

Objectives: To determine whether bronchoscopic intervention could be immediately successful in restoring airway patency and obviate the need for continued mechanical ventilation in a homogeneous group of inoperable mechanically ventilated patients with ARF and CAO from NSCLC.

Methods: A retrospective study of 12 consecutive intubated and mechanically ventilated patients with inoperable or unresectable CAO from NSCLC referred for therapeutic bronchoscopic intervention between January 2003 and December 2008.