Publications by authors named "Stephanie L Howe"
Article Synopsis
- Amyotrophic lateral sclerosis (ALS) is a deadly neurodegenerative disease that presents various clinical challenges and complex genetics, complicating understanding and treatment efforts.* -
- To address this, researchers created human induced pluripotent stem cells (iPSCs) from different ALS patients - including sporadic and familial cases - as well as healthy controls.* -
- These iPSCs can be used to develop 2D and 3D models of ALS, aiding in the study of disease mechanisms and the identification of potential therapies.*
Background And Objectives: Altered metabolism is observed in amyotrophic lateral sclerosis (ALS). However, without a standardized methodology to define metabolic changes, our understanding of factors contributing to and the clinical significance of altered metabolism in ALS is limited.
Methods: We aimed to determine how geographic variation in metabolic rates influences estimates and accuracy of predicted resting energy expenditure (REE) in patients with ALS and controls, while validating the effectiveness of cohort-specific approaches in predicting altered metabolic rate in ALS.
Background And Purpose: Loss of appetite contributes to weight loss and faster disease progression in amyotrophic lateral sclerosis (ALS). Impairment of appetite control in ALS may include altered production or action of orexigenic (i.e.
View Article and Find Full Text PDFBackground And Purpose: To establish the utility of venous creatinine as a biomarker to monitor loss of fat-free mass in patients with amyotrophic lateral sclerosis (ALS).
Methods: In this multicenter natural history study, body composition and venous creatinine were assessed in 107 patients with ALS and 52 healthy controls. Longitudinal patterns of venous creatinine and its association with the risk of death during follow-up were determined in a cohort of patients with ALS from Australia (n = 69) and the Netherlands (n = 38).