Synthesis of Polyglycerol, Porphyrin-Cored Dendrimers Using Click Chemistry.

Polyglycerol, porphyrin-cored dendrimers were synthesized by the click reaction of azide-cored polyglycerol dendrons and octaazidoporphyrin . The dendrons were synthesized divergently starting with TBDPS protected allyl alcohol . Two, three and four cycles of dihydroxylation-allyl etherification gave dendrons [G-2.

Cross-linking dendrimers with allyl ether end-groups using the ring-closing metathesis reaction.

A third generation Frechet-type dendrimer containing 24 allyl ether end-groups was synthesized, cross-linked using the ring-closing metathesis (RCM) reaction, and the core was removed hydrolytically without significant fragmentation. The results are analogous to those previously reported for homoallyl ether dendrimers (Wendland, M. S.

Organic nanoparticles whose size and rigidity are finely tuned by cross-linking the end groups of dendrimers.

Dendrimers with molecular weights ranging from ca. 2700 to 11 000 and from 16 to 64 homoallyl ether end groups were cross-linked using the Grubbs ring-closing metathesis reaction. A combination of SEC, MALDI-TOF-MS, and AFM were used to characterize the cross-linked nanoparticles.